Robin Cook - Shock

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Shock
Robin Cook
The human egg cell, or oocyte, that was snared by the slight suction exerted through the blunt end of the
holding pipette was no different from its approximately five dozen siblings. It was merely the closest to
the end of the tiny glass rod when the rod came into the technician's view. The group of oocytes was
suspended in a drop of culture fluid under a thin layer of mineral oil beneath the objective of a powerful
dissecting microscope. The oil prevented evaporation. It was vitally important that the environment of
these living cells stay in an appropriate steady state. Like the others the fixated oocyte appeared healthy
with an appropriate granularity of its cytoplasm. Also like the others its chromatin, or DNA, fluoresced
under ultraviolet light like miniature fireflies in a pea-soup fog. The only evidence of the cell's earlier rude
aspiration from its developing follicle were the ragged remains of its corona radiata of granulosa cells
adherent to the comparatively dense envelope called the zona pellucida. All of the oocytes had been
yanked from their ovarian nest prematurely and then encouraged to mature in vitro. At that moment they
were ready for spermatic penetration, but that was not to be the case. These female gametes were not to
be fertilized.
Another pipette entered the visual field. This was a more lethal-appearing instrument, particularly
beneath the microscope's strong magnification. Although in reality only twenty-five millionths of a meter in
diameter, it looked like a sword with a tip beveled to needlepoint sharpness. Inexorably it closed in on
the hapless, immobile gamete and indented the cell's zona pellucida. Then with a practiced tap by the
experienced technician on the pipette's controlling micrometer, the end of the pipette was plunged into the
cell's interior. Advancing to the fluorescing DNA, a slight suction was applied to the pipette's interior and
the DNA disappeared into the glass rod.
Later, after ascertaining that the gamete and its sisters had withstood the enucleation ordeal as well as
could be expected, the cell was again immobilized. Another beveled pipette was introduced. This time
the penetration was limited to the zona pellucida, sparing the oocyte's cell membrane, and instead of
suction being applied, a tiny volume of fluid was introduced into what's known as the perivitelline space.
Along with the fluid came a single, comparatively small, spindle-shaped adult cell obtained from a buccal
scraping of an adult human's mouth.
The next step involved suspending the gametes with their paired adult epithelial cells in four milliliters of
fusion medium and placing them between the electrodes of a fusion chamber. When the gametes were all
appropriately aligned, a switch was thrown sending a ninety-volt electrical pulse through the medium for
fifteen millionths of a second. The result was the same for all the gametes. The shock caused the
membranes between the enucleated gametes and their adult cell partners to dissociate momentarily, fusing
the two cells.
Following the fusion process the cells were placed in an activation medium. Under chemical stimulation
each gamete that had been ready for fertilization prior to the removal of its DNA now worked magic with
its adopted full complement of chromosomes. Following a mysterious molecular mechanism, the adult
nuclei forsook their previous epithelial duties and reverted to their embryonic roles. After a short period
of time each gamete began to divide to form individual embryos that would soon be ready for
implantation. The donor of the adult cells had been cloned. In fact, he'd been cloned approximately sixty
times...
PROLOGUE
APRIL 6, 1999
"ARE YOU COMFORTABLE?" Dr. Paul Saunders asked his patient, Kristin Overmeyer, who lay on
the aged operating table clothed only in a backless hospital johnny. "I guess," Kristin answered, although
she was not comfortable at all. Medical environments never failed to evoke a level of anxiety in her that
was tolerable but not pleasant, and the present room was particularly disagreeable. It was an ancient
operating theater the decor of which was the absolute opposite of the sterile utilitarianism of a modern
medical facility. Its walls were surfaced in bile-green, cracked tile with dark splotches presumably from
old blood staining the grout. It looked more like a scene in a gothic horror movie set in the nineteenth
century than a room currently in use. There were also tiers of observation seats that disappeared up into
the gloom beyond the reach of the overhead surgical light. Thankfully the seats were all empty.
" 'I guess' doesn't sound too convincing," Dr. Sheila Donaldson said from the side of the operating table
opposite Dr. Saunders. She smiled down at the patient, although the only observable effect was a
crinkling at the corners of her eyes. The rest of her face was hidden behind her surgical mask and hood.
"I wish this was over," Kristin managed. At that moment, she wished she hadn't volunteered for the egg
donation. The money would provide her with a degree of financial freedom that few of her fellow
Harvard students enjoyed, but that seemed less important now. Her only consolation was that she knew
she'd soon be asleep; the minor procedure she was about to undergo would be painless. When she'd
been offered the choice of general anesthesia or local she chose the former without a moment's hesitation.
The last thing she wanted to be was awake while they pushed a foot-long aspiration needle into her belly.
"I trust we are going to be able to get this done today," Paul said sarcastically to Dr. Carl Smith, the
anesthesiologist. Paul had a lot to do that day and had scheduled only forty minutes for the upcoming
procedure. Between his experience with the operation and his facility with the instruments, he thought he
was being generous allotting forty minutes. The only holdup was Carl; Paul couldn't begin until the patient
was under, and minutes were inexorably ticking away.
Carl didn't respond. Paul was always in a hurry. Carl concentrated on taping the precordial
stethoscope's head onto Kristin's chest. He already had the IV running, the blood pressure cuff
positioned, the EKG leads attached, and the pulse oximeter in place. Satisfied with the auscultatory
sounds he heard through his earpiece, he reached over and pulled his anesthesia machine closer to
Kristin's head. All was ready.
"Okay, Kristin,' Carl said reassuringly. "As I explained to you earlier I'm going to give you a bit of 'milk
of amnesia.' Are you ready?"
"Yes," Kristen said. As far as she was concerned, the sooner the better.
"Have a good little sleep," Carl said. "The next time I'll be talking with you will be in the recovery area."
Such was Carl's usual comment to his patient just before beginning anesthesia, and indeed it was the
usual course of events. But on this occasion it was not to be. Blithely unaware that disaster was imminent,
Carl reached for the IV line where he had the anesthetic agent piggybacked. With practiced ease he gave
the patient a predetermined amount based on her weight, but on the low end of the recommended
dosage. It was the Wingate Infertility Clinic's policy for outpatient anesthesia to use the least amount
appropriate of any particular drug. The goal was to ensure the patient's same-day discharge, since the
clinic's inpatient facilities were limited.
As the induction dose of propofol entered Kristin's body, Carl dutifully watched and listened to his
monitoring devices. All seemed in order.
Sheila chuckled beneath her mask. "Milk of amnesia" was Carl's humorous sobriquet for the anesthetic
agent propofol, which was Dispensed as a white liquid, and the term never failed to tickle her funny bone.
"Can we start?" Paul demanded. He shifted his weight. He knew he couldn't begin yet, but he wanted to
communicate his impatience and displeasure. They shouldn't have called him until all was ready. His time
was too valuable for him to be standing idly while Carl messed around with all his toys.
Continuing to ignore Paul's peevishness, Carl concentrated on testing Kristin's level of consciousness.
Satisfied she'd reached an appropriate state, he injected the muscle relaxant mivacurium, which he
preferred over several others for its rapid spontaneous recovery time. When the mivacurium had taken
effect, he skillfully slipped in an endotracheal tube to ensure control of Kristin's airway. Then he sat
down, attached the anesthesia machine, and motioned to Paul that everything was set.
"It's about time," Paul mumbled. He and Sheila quickly draped the patient for laparoscopy. The target
was the right ovary.
Carl settled back after making the appropriate entries into the anesthesia record. His role at that point
was to watch his monitors while maintaining anesthesia by carefully titrating the patient's state of
consciousness with a continuous propofol infusion.
Paul moved quickly, with Sheila anticipating his every move. Along with Constance Bartolo, the scrub
nurse, and Marjorie Hickam, the circulator, the team worked with metronomic efficiency. At this point
there was no conversation.
Paul's first goal was to introduce the trocar of the insufflation unit to fill the patient's abdominal cavity
with gas. It was the creation of a gas-filled space that made the laparoscopic surgery possible. Sheila
helped by grabbing two bites of skin alongside Kristin's belly button with towel clips and pulling up on the
relaxed abdominal wall. Meanwhile, Paul made a small incision at the umbilicus and then proceeded to
push in the nearly foot-long Veress insufflation needle. In his experienced hands two distinct pops could
be felt as the needle passed into the abdominal cavity. While holding the needle firmly at its serrated
collar, Paul activated the insufflation unit. Instantly, carbon dioxide gas began to flow into Kristin's
abdominal cavity at a rate of a liter of gas per minute.
As they waited for the appropriate amount of gas to enter, disaster struck. Carl was preoccupied,
watching his cardiovascular and respiratory monitors for telltale signs of the increasing intra-abdominal
pressure, and failed to see two seemingly innocuous events: namely a fluttering of Kristin's eyelids and a
slight flexion of her left leg. Had Carl or anyone else noticed these movements they would have sensed
that Kristin's level of anesthesia was becoming light. She was still unconscious but close to waking, and
the discomfort of the increasing pressure in her belly was serving to rouse her.
Suddenly Kristin moaned and sat up. She didn't get all the way up; Carl reacted by reflex, grabbing her
rising shoulders and forcing her back down. But it was too late. Her rising off the table forced the Veress
needle in Paul's hand to plunge deeper into her belly, where it penetrated a large intra-abdominal vein.
Before Paul could stop the insufflation unit, a large bolus of the gas entered Kristin's vascular system.
"Oh my God!" Carl cried as he heard in his earpiece the beginnings of the ominous telltale mill-wheel
murmur as the gas reached her heart; a threshing sound like the agitation cycle of a washing machine.
"We've got a gas embolism," he yelled. "Get her on her left side!"
Paul yanked out the bloody needle and tossed it to the side, where it clanked against the tile floor. He
helped Carl roll Kristin over in a vain attempt to keep the gas isolated in the right side of her heart. Paul
then leaned on her to keep her in position. Although still unconscious, she fought back.
Meanwhile, Carl rushed to insert, as aseptically as possible, a catheter into Kristin's jugular vein. Kristin
resisted and struggled against the weight on top of her. Inserting the catheter was like trying to hit a
moving target. Carl thought about increasing the propofol or giving her more mivacurium, but was
reluctant to take the time. At last he succeeded with the catheterization, but when he drew back on the
plunger of the syringe all he got was a bloody froth. He did it again with the same result. He shook his
head in dismay, but before he could say anything Kristin briefly stiffened, then convulsed. Her body was
racked by a full-blown grand mal seizure.
Frantically Carl dealt with this new problem while he battled the sinking feeling in his own gut. He knew
all too well that anesthesiology was a profession marked by numbing, repetitive routine occasionally
shattered by episodes of pure terror, and this was as bad as it got: a major complication with a young,
healthy person undergoing a purely elective procedure.
Both Paul and Sheila had stepped back with their sterile, gloved hands clasped in front of their gowned
chests. Along with the two nurses, they watched as Carl struggled to terminate Kristin's seizure. When it
was over, and Kristin was again on her back motionless, no one spoke. The only sound other than the
muted noise of a radio coming through the closed door to the sterilizer room was the anesthesia machine
breathing for the patient.
"What's the verdict?" Paul said finally. His voice was emotionless, and it echoed in the tiled space.
Carl breathed out like a balloon deflating. Reluctantly he reached forward with two index fingers and
pulled back Kristin's eyelids. Both pupils were widely dilated and did not react to the brightness of the
overhead light. He took his own penlight from his pocket and shined the beam into Kristin's eyes. There
was no reaction whatsoever.
"It doesn't look good," Carl croaked. His throat was dry. He'd never had such a complication.
"Meaning?" Paul demanded.
Carl swallowed with difficulty. "Meaning my guess would be that she's stroked out. I mean, a minute ago
she was light, now she's gorked out. She's not even breathing on her own."
Paul's head bobbed up and down perceptively as he pondered this information. Then he snapped off his
gloves, tossed them on the floor, and undid his mask, which he allowed to fall forward onto his chest. He
looked at Sheila. "Why don't you continue with the procedure? At least you'll get some practice. And do
both sides."
"Really?" Sheila questioned.
"No sense being wasteful," Paul said.
"What are you going to do?" Sheila asked.
"I'm going to find Kurt Hermann and have a chat," Paul said as he untied and pulled off his gown. "As
unfortunate as this incident is, it's not as if we haven't anticipated such a disaster, and at least we've
planned for it."
"Are you going to inform Spencer Wingate?" Sheila asked. Dr. Wingate was the founder and titular head
of the clinic.
"That I don't know," Paul said. "It depends. I prefer to hold off and see how events play out. What do
you know about Kristin Overmeyer's arrival today?"
"She came in her own car," Sheila said. "It's out in the parking lot."
"She came alone?"
"No. As we advised her, she brought a friend," Sheila said. "Her name is Rebecca Corey. She's out in
the main waiting area."
As Paul started for the door his eyes locked onto Carl's.
"I'm sorry," Carl said.
Paul hesitated for a moment. He felt like telling the anesthesiologist what he thought of him, but changed
his mind. Paul wanted to keep a cool head, and getting into a conversation with Carl at that point would
have gotten him all worked up. It had been enough that Carl had kept him waiting for so long.
Without even bothering to change out of his surgical scrubs, Paul snatched a long white doctor's coat
from the room that served as the surgical lounge. He pulled the coat on as he descended the metal stairs
in the stairwell. Passing the first floor, he exited out onto the lawn, which was showing the first signs of
spring. With the coat clutched around himself against the blustery early April New England wind, he
hurried down toward the clinic's stone gatehouse. He found the chief of security behind his scarred and
worn desk, hunched over his department's schedule for the month of May.
If Kurt Hermann was surprised by the sudden arrival of the man who ran the Wingate Clinic, he didn't
show it. Other than looking up, his only acknowledgment of Paul's presence was a slight questioning
elevation of his right eyebrow.
Paul grabbed one of the straight-backed chairs that lined the sparse office and sat down in front of the
security chief.
"We have a problem," Paul said.
"I'm listening," Kurt said. His chair squeaked as he leaned back.
"We've had a major anesthetic complication. Catastrophic, actually."
"Where's the patient?"
"Still in the OR, but she'll be out shortly."
"Name?"
"Kristin Overmeyer."
"Did she come alone?" Kurt asked as he wrote Kristin's name down.
"No. She came by car with a friend named Rebecca Corey. Dr. Donaldson said she's in the main waiting
room."
"Make of the car?"
"I have no idea," Paul admitted.
"We'll find out," Kurt said. He raised his steely blue eyes to meet Paul's.
"This is what we hired you people for," Paul stated tersely. "I want you to handle it, and I don't want to
know anything."
"No problem," Kurt said. He laid his pen down carefully as if it were fragile.
For a moment the two men stared at each other. Then Paul stood up, turned, and disappeared out into
the gusty April morning.
ONE
OCTOBER 8, 1999 11:15 P.M.
SO LET ME GET THIS straight,' Joanna Meissner said to Carlton Williams. The two friends were
sitting in the dark inside Carlton's Jeep Cherokee in a no-parking zone on Craigie Street alongside the
Craigie Arms apartment building in Cambridge, Massachusetts. "You've decided that it would be best for
us to wait to be married until after you finish your surgical residency some three or four years from now."
"I haven't decided anything," Carlton said defensively. "We're having a discussion here."
Joanna and Carlton had been out to dinner in Harvard Square that Friday evening and had been
enjoying themselves until Joanna ;id brought up the sore subject of their long-term plans. As usual, from
that moment on, the tone of the conversation had deteriorated. They had been over this thorny issue
many times in the past as a consequence of their engagement. Theirs was a quintessentially long affair;
they had known each other since kindergarten and had been dating each other exclusively since the ninth
grade.
"Listen," Carlton said soothingly. "I'm just trying to think of what's best for both of us."
"Oh, bull!" Joanna blurted. Despite her vow to herself to stay calm, she could feel anger brewing in her
gut as if she were a nuclear reactor about to go critical.
"I'm serious," Carlton said. "Joanna, I'm working my tail off. You know how often I'm on call. You
know the hours. Being a resident at the MGH is a hell of a lot more demanding than I'd ever guessed."
"What difference does that make?" Joanna snapped, unable to keep the irritation she felt from being
painfully obvious. She couldn't help feeling betrayed and rejected.
"It makes a lot of difference," Carlton persisted. "I'm exhausted. I'm no fun to be with. I can't have a
normal conversation outside of what's going on in the hospital. It's pathetic. I don't even know what's
happening in Boston, much less the world."
"That kind of comment might have some validity if we were dating casually. But the fact of the matter is
we've been seeing each other for eleven years. And up until I broached this delicate issue of setting a
date tonight, you were enjoying yourself, and you were perfectly fun to be with."
"I certainly love seeing you..." Carlton said.
"That's reassuring," Joanna interjected sarcastically. "What I find particularly ironic about this situation is
that you're the one who asked me to marry you, not vice versa. The trouble is, that was seven years ago.
I'd say that suggests your ardor has significantly cooled."
"It hasn't," Carlton protested. "I do want to marry you."
"I'm sorry, but you're not convincing. Not after all this time. First you wanted to graduate from college.
That was fine. No problem. I thought that was appropriate. Then you thought you should just get through
the first two years of medical school. Even that was okay with me since I could get most of my Ph.D.
coursework out of the way. But then you thought it best to put things off until you got yourself all the way
through medical school. Are you detecting a pattern here or is it just me? Then the issue became getting
the first year of residency behind you. Stupid me even accepted that, but now it's the whole residency
business. What about the fellowship deal you talked about last month? And then after that you might even
think it best to wait while you set up your practice."
"I'm trying to be rational about this," Carlton said. "It's a difficult decision, and it behooves us to weigh
the pros and cons..."
Joanna was no longer listening. Instead her emerald-green eyes wandered away from the face of her
fiancé who, she recognized, wasn't even looking at her as he spoke. In fact, he'd avoided looking at her
throughout this conversation; as far as she could tell, he'd only intermittently met her glare during her
monologue. With unseeing eyes she stared straight ahead into the middle distance. All at once it was as if
she had been slapped across the face by an invisible hand. Carlton's suggestion of yet another delay in
setting a marriage date had spawned an epiphany, and she found herself laughing, not out of humor but
disbelief.
Carlton halted in midsentence while enumerating the pros and the cons of getting married sooner rather
than later.
"What are you laughing about?" he asked. He raised his eyes from watching himself fumble with the
ignition keys and gazed at Joanna in the car's dim interior. Her face was silhouetted against the dark side
window by a distant streetlamp whose light fingered its way through the windshield. Her sleek and
delicate profile was limned by her lustrous flaxen hair, which appeared to glow in the half light.
Diamond-like flashes glistened from her starkly white teeth just visible through her slightly parted, full lips.
To Carlton, she was the most beautiful woman in the world even when she was badgering him.
Ignoring Carlton's question, Joanna continued her soft, mirthless laugh as the clarity of her revelation
sharpened. Precipitously, she'd come to acknowledge the validity of what her roommate Deborah
Cochrane and her other female friends had been hawking all along, namely that marriage in and of itself
should not be her life's goal. They'd been right after all: she'd been programmed by the totality of her
suburban Houston upbringing. Joanna couldn't believe she'd been so stupid for so long and so resistant to
question a value system she'd so blindly accepted. Thankfully, while treading water waiting for Carlton,
she'd been smart enough to lay the foundation of a rewarding career. She was only a thesis away from a
Ph.D. from Harvard in economics combined with extensive computer skills.
"What are you laughing about?" Carlton persisted. "Come on! Talk to me!"
"I'm laughing at me," Joanna said finally. She turned to look at her fiancé. He appeared perplexed, with
his brows tightly knit.
"I don't understand," Carlton said.
"That's curious," Joanna said. "I see everything rather clearly."
She glanced down at the engagement ring on her left hand. The diamond solitaire sucked in the weak
available light and threw it back at Joanna with surprising intensity. The stone had been Carl-ton's
grandmother's, and Joanna had been thrilled with it, mostly because of its sentimental value. But now it
seemed like a vulgar neon reminder of her own gullibility.
A sudden sense of claustrophobia gripped Joanna. Without any warning she unlatched the door, slid out,
and stood up on the curb.
"Joanna!" Carlton called. He leaned across the car's center console and peered up into Joanna's face.
Her expression was one of fierce resolve. Her usually soft lips were set in grim determination.
Carlton started to ask Joanna what was the matter, although he knew all too well. Before he could even
get the sentence out, the car door slammed in his face. Pushing himself back upright, he groped for the
passenger-side window button. When the window opened, Joanna leaned in. Her expression hadn't
changed.
"Don't insult me by asking what's the matter," she said.
"You're not being very adult about this," Carlton stated firmly.
"Thank you for your unbiased assessment," Joanna retorted. "I also want to thank you for making
everything so clear for me. It certainly makes it easier to make up my mind."
"Make up your mind about what?" Carlton asked. The newly found firmness of his voice vanished. In its
place was a definite quaver. He had a premonition about what was coming, and it was accompanied by a
sinking feeling in the pit of his stomach.
"About my future," Joanna said. "Here!" She extended her clenched fist with the obvious intention of
giving something to Carlton.
Carlton reached out hesitantly with a cupped palm. He felt something cold drop into his hand. Glancing
down, he found himself staring at his grandmother's diamond.
"What's this all about?" Carlton stammered.
"I think it's pretty clear," Joanna said. "Consider yourself free to finish your residency and whatever else
your little heart desires. I certainly don't want to think of myself as a drag."
"You're not serious?" Carlton questioned. Caught completely off guard by this sudden turn of events, he
was befuddled.
"Oh, but I am," Joanna said. "Consider our engagement officially over. Good night, Carlton."
Joanna turned and walked back along Craigie Street toward Concord Avenue and the entrance to the
Craigie Arms. Her apartment was on the third floor.
After a brief struggle with the door release Carlton leaped from his Cherokee and ran after Joanna,
who'd already reached the corner. A few deep red maple leaves, which had fallen from the tree that very
day, wafted in his wake. He caught up to his former fiancée as she was about to enter her apartment
building. He was out of breath. He was clutching the engagement ring in his fist.
"All right," Carlton managed. "You've made your point. Here, take the ring back." He extended his hand.
Joanna shook her head. Her grim determination had disappeared. In its place was a tenuous smile. "I
didn't give the ring back as a mere gesture or machination. Nor am I actually angry. You obviously don't
want to get married now, and all at once, I don't either. Let's give it a rest. We're still friends."
"But I love you," Carlton blurted.
"I'm flattered," Joanna said. "And I suppose I still love you, but things have been dragging on for too
long. Let's go our separate ways, at least for now."
"But
"Good night, Carlton," Joanna said. She pushed herself up onto her tiptoes and gave Carlton's cheek a
brush with her lips. A moment later she was in the elevator. She hadn't looked back.
Putting her key in her apartment door she noticed she was trembling. Despite her airy dismissal of
Carlton, she felt her emotions rumbling just below the surface.
"Wow!" her roommate Deborah Cochrane exclaimed. She checked the task bar on her computer to see
the time. "Rather early for a Friday night. Wussup?" Deborah was dressed in oversized
Harvard-emblazoned sweats. In comparison with the soft, porcelain femininity of her roommate, she was
mildly tomboyish with short dark hair, a
Mediterranean olive complexion, and an athletic build. Her facial features contributed by being stronger
and more rounded than Joanna's yet no less feminine. All in all, the roommates complemented each other
and emphasized each other's natural attractiveness.
Joanna didn't respond as she hung up her coat in the hall closet. Deborah watched her closely as she
came into their sparsely furnished living room and collapsed on the couch. She tucked her feet under
herself and only then met Deborah's inquisitive eyes.
"Don't tell me you guys had a fight," Deborah said.
"Not a fight per se," Joanna said. "Just a parting of ways."
Deborah's jaw dropped. For the six years she'd known Joanna, from freshman orientation onward,
Carlton had been a fixture in Joanna's life. As far as she was concerned there'd not been the slightest hint
of discord within the relationship. "What happened?" she asked with astonishment.
"I suddenly saw the light," Joanna said. There was a slight trill to her voice that Deborah noticed
instantly. "My engagement is off, and, more importantly, I'm not going to count on getting married,
period. If it happens, fine, but if it doesn't, that's okay too."
"My word!" Deborah said, unable to keep the glee from her voice. "This doesn't sound like the 'butter
cream frosting, silky bridesmaids' dresses' girl that I've come to love. Why the change of heart?" Deborah
considered Joanna's march toward marriage almost religious in its unswerving intensity.
"Carlton wanted to postpone the wedding until after his residency," Joanna said. In short order, she
recounted the last fifteen minutes of her date with Carlton. Deborah listened with rapt attention.
"Are you all right?" Deborah asked when Joanna fell silent. She leaned forward to peer more directly
into Joanna's eyes.
"Better than I would have guessed," Joanna admitted. "I feel a little shaky, I suppose, but all things
considered, I'm doing okay."
"Then this calls for a celebration," Deborah exclaimed. She stood up and bounced into the kitchen. "I've
been saving that bottle of champagne cluttering up the fridge for months," she called over her shoulder.
"This is the time to open it."
"I suppose,' Joanna managed. She didn't feel much like celebrating, but resisting Deborah's enthusiasm
would have taken too much effort.
"All right!" Deborah exclaimed as she returned with the champagne in one hand and two flutes in the
other. She knelt at the coffee table and attacked the bottle. The cork came away with a resounding pop
and caromed off the ceiling. Deborah laughed but noticed that Joanna didn't.
"Are you sure you're okay?" Deborah asked.
"I have to say, it's a big adjustment."
"That's an understatement," Deborah averred. "Knowing you as well as I do, it's the equivalent of Saint
Paul falling on the way to Damascus. You've been programmed by the Houston social scene toward
marriage since you were nothing but a twinkle in your mother's eye."
Joanna laughed despite herself.
Deborah poured the champagne too quickly. Both glasses filled, mostly with fizz, and spilled out on the
table. Undeterred, Deborah snatched up the flutes and handed one to Joanna. Then she made Joanna
clink glasses with her.
"Welcome to the twenty-first century social scene," Deborah said.
Both women lifted their stemware and tried to drink. They coughed on the foam and laughed. Not
wanting to lose the moment, Deborah quickly took both glasses into the kitchen, rinsed them, and
returned. This time she poured more carefully by letting the champagne run down the side of the glass.
When they drank, it was mostly liquid.
"Not the greatest bubbly," Deborah admitted. "But it's not surprising. David gave it to me way back
when. Unfortunately he was a cheapskate from the word go." Deborah had broken off a four-month
relationship with her most recent boyfriend, David Curtis, the week before. In sharp contrast to Joanna's,
her longest relationship had been less than two years and that was way back in high school. In many
ways the two women couldn't have been more different. Instead of the affluent southern suburban social
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ShockRobinCookThehumaneggcell,oroocyte,thatwassnaredbytheslightsuctionexertedthroughthebluntendoftheholdingpipettewasnodifferentfromitsapproximatelyfivedozensiblings.Itwasmerelytheclosesttotheendofthetinyglassrodwhentherodcameintothetechnician'sview.Thegroupofoocyteswassuspendedinadropofculturefluid...

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