2 T. DE ANGELIS, J. GARG, Q. ZHOU
[21], [22]), where the problem above was formulated and solved for the first time. The finite-
horizon version of the problem was studied by Gapeev and Peskir [12], general one dimensional
diffusions were considered by Gapeev and Shiryaev [13] and, in particular, quickest detection
for Bessel and Ornstein-Uhlenbeck processes was studied by Peskir with Johnson [15] and
with Glover [14], respectively. Recently, Peskir and Ernst [11] studied the detection of a drift
in a coordinate of a multi-dimensional Brownian motion. Further references on this subject
and the related “disorder problem” can be found in [19, Chapter VI] and in Shiryaev’s survey
paper [24].
1.2. Motivating examples for our study. To motivate our study and explain how it
extends the classical quickest detection problem, it is convenient to think of the process X
as a signal emitted by a system and of θas the time at which the operating mode of the
system changes (e.g., because of a mechanical failure or because of an external disturbance).
The interpretation of the payoff in (1.2) is as follows: at time τthe appearance of a drift is
“declared”; if τ < θ the cost of a “false alarm” is α, whereas if τ > θ the cost of a “delayed
alarm” is β(τ−θ). In order to calculate such costs, some sort of test must be performed on the
system that reveals without error whether the drift has appeared or not. Upon observing a
negative outcome from the test, in some applications one resumes monitoring the system until
the next stopping decision is made (e.g. in the radar operation problem discussed in [24]).
In reality, a “perfect” inspection of the system is often impossible, particularly when the
underlying disorder is challenging to identify, due to the possibility of false negatives resulting
from the test. In those cases, it makes sense to allow multiple (costly) inspections of the
system. Problems of this kind naturally arise in the healthcare context, where we may think
of Xas an indicator of the general health condition of an individual and of θas the time of
the onset of some disease. The appearance of the drift µin the dynamics of Xmodels the
appearance of some symptoms, which may be difficult to detect at first or perhaps could be
mistaken for some normal tiredness or stress. Indeed, it is well known that the detection of
complex diseases, like cancer in early stages, may require multiple tests and false negatives
are not uncommon (see, e.g., Bartlett et al. [3] and Verbeek et al. [26]). Another example is
suggested by the extensive use of COVID-19 tests that we witnessed in recent years. In that
case, early symptoms could vary wildly across different individuals, and it is not easy to tell
them apart from those of a normal cold. Testing was key but the false negative rate of the
PCR test can be as high as 10%, according to Kanji et al. [16].
Variants of the classical quickest detection problem accounting for imperfect inspections
could also cover situations in which a device which is positioned in a remote location sends
signals in continuous time to headquarters (e.g., a satellite). A change in the form of the
signal may indicate a faulty part in the device. However, at least initially the inspections
would be carried out “remotely” and would therefore be subject to error.
It turns out that the mathematical literature has not yet considered quickest detection
problems in such situations, and this work represents the first attempt in this direction. For
simplicity, we do not consider false positives in our analysis, but in Section 6we point to
several generalizations of our model. This simplification is not overly restrictive, because in
many applications where a statistical hypothesis testing procedure is used to determine 1{τ <θ},
the false positive rate is controlled at a minimum level (for example, in the aforementioned
work on COVID-19 testing [16], the false positive rate is assumed to be zero).
1.3. Our model and mathematical contribution. To account for false negatives, we
propose a new variant of the quickest detection problem. We describe it informally here and
we will rigorously formulate the problem in Section 2. We still assume the observed system’s
dynamics be modeled by the process Xgiven in (1.1). Unlike the classical formulation, we
assume that at the chosen stopping time τ, the optimizer performs an imperfect inspection on